In May 2001, Jeffrey Pierce walked out of an Oklahoma prison after being exonerated by DNA testing. His innocence was proven during the investigation of Joyce Gilchrist, formerly a scientist at the Oklahoma City Police Laboratory, for falsifying testimony and shoddy forensic analysis. Pierce's case was one of more than one thousand involving Gilchrist's testimony.

Pierce was convicted in 1986 of raping and robbing an Oklahoma City woman. The prosecution relied on the testimony of their forensic expert, Joyce Gilchrist. In 1985, the victim was returning to her apartment complex when she was confronted, raped, and sodomized. Pierce was part of a landscaping crew that had been working around the apartment complex. The initial description of the perpetrator did not match Pierce and, when he was pointed out to her, the victim could not identify him. Months later, police arrested Pierce and placed his picture in a photo lineup wearing a tan shirt, which was an element of the victim's initial description of her attacker. The victim identified him from this array.

At trial, Gilchrist claimed that hairs collected from the victim's apartment, where the rape took place, matched Pierce's hair. These findings would be disputed in 2001 by the FBI's laboratory's analysis of the hairs. DNA testing would not only confirm that Gilchrist's findings were wrong but also preliminarily matched a felon in Oklahoma.

Pierce now lives in Michigan with his family, including twin sons who were infants at the time of his conviction. He had spent fifteen years in prison.